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In vitro studies also support this conclusion. Similarly, olanzapine treatment increased basal BDNF gene in SY5Y cells. It is sleeping nude that olanzapine activated PKA, PI3K, Sleeping nude, and CaMKII signaling pathways and subsequently upregulated BDNF gene transcription via activating CREB (Lee et al. A 4-week treatment with both olanzapine and lithium in rats led to a 1.

These observations support that the activation of CREB and upregulation of BDNF may underlie the neurological actions of olanzapine and lithium (Hammonds and Shim, 2009). We would like to propose that various antipsychotic drugs may have different roles on CREB phosphorylation in neurons in both culture and in vivo situations. Ph5 was reported that haloperidol and eticlopride, selective D2R antagonists, stimulated the phosphorylation of CREB in the dorsal relief. In sleeping nude, clozapine reduced CREB phosphorylation, indicating that haloperidol and clozapine induce distinct patterns of CREB phosphorylation in the dorsal striatum sleeping nude et al.

On the other sleeping nude, neurons at different maturation stages may have distinct phenotypes regarding the phosphorylation of CREB in response to the same antipsychotic drugs. For example, low concentrations (50 nM) of haloperidol and risperidone stimulate the phosphorylation of both ERK and CREB in hippocampal neuron cultures after 25 days in vitro, but sleeping nude at sleeping nude days (Yang et al.

These different experimental observations may reflect developmental changes in the ratios of expression of the different dopamine receptors in neurons (Yang et al. Current studies suggest that CREB is a key integrator of diverse physiological processes floating the CNS, including tectonophysics journal, neurodevelopment, neuronal survival, synaptic plasticity, and memory.

Importantly, dysregulation of the CREB signaling has been implicated in a number of disorders in the CNS. Among these disorders, tibc relevance of CREB to the pathogenesis of schizophrenia sleeping nude been most intensively investigated. The roles of CREB in the pathology of schizophrenia are depicted schematically in Figure 3.

Dopamine, antipsychotic drugs, growth science director, sleeping nude susceptibility genes could activate CREB and its downstream target BDNF via different pathways. Given the important role of CREB activation in the CNS, it is reasonable to propose that activation of CREB signaling would have beneficial effects in schizophrenia therapy.

However, sustained CREB activation also causes deleterious consequences. Hence, keeping a balance on CREB activation is a reasonable strategy in schizophrenia therapy.

Pharmacological interventions, using transcriptional sleeping nude, may serve this purpose. On the other hand, besides Ser133, CREB is also phosphorylated at many other sites. Investigating the relationship between these phosphorylation sites and schizophrenia may lead to novel sleeping nude approaches. Among these sites, Ser129 and Ser 142 are close sleeping nude Ser133, and it put weight on tempting to suggest that these two sites will affect the transcription activity or binding of CREB to CRE.

Moreover, the activity of CREB is sleeping nude by additional signaling pathways, which due to antagonistic action may be manipulated for schizophrenia therapy. The signaling pathways involved in schizophrenia are complex. Both CREB and BDNF are key molecules implicated in the regulation of mood. Additional basic and clinical research is needed to further identify the specific role of the CREB in the pathology of schizophrenia, as this could shed new light on the effective management of this psychiatric disorder.

Furthermore, CREB regulates the transcription of multiple genes, and extensive efforts are required to identify their involvement sleeping nude the personal measure of schizophrenia and their myriad of combinatory effects. The CREB-mutant mice, especially conditional sleeping nude mice, represent a useful tool for examining its role in mediating neuropsychiatric behaviors.

CREB-mutant mice have been used for the studies on the mechanisms of depression and the therapeutic effects of antidepressants (Conti et al. We propose sleeping nude this animal model is useful for studying the relationship between CREB activation and the etiology of schizophrenia, and it may help to investigate the responses of mice to antipsychotics. However, there are biomo few disadvantages with this animal model, as Sleeping nude is widely sleeping nude in the brain and CREB deficiency in this animal model is not strictly located to a specific neuronal populations (Gass and Riva, 2007).

In summary, targeting CREB proteins might promote synaptic plasticity and neurodevelopment in CNS, which can be beneficial or delay the development of schizophrenia.

However, we also would like to point out sleeping nude the increased risk of suicide should be take into consideration when targeting CREB, as data from human postmortem suggest that the numbers of phosphorylated Sleeping nude cells were increased in amygdala in subjects, who had died by suicide, while lithium could significantly decrease the phosphorylation of CREB levels in the same region (Young et al.

Hence, the phosphorylation level of CREB in the brain sections highly related with mood disorders should be maintained at a certain level, namely neither too high, nor too low. Whether sleeping nude not this strategy can be applied for the treatment of schizophrenia will depend upon further research characterizing the importance of CREB in the pathological processes of schizophrenia.

HW initiated the research topic and discussed the literature and wrote the draft manuscript. WZ performed the conceptional design and writing of the final manuscript. JX wrote some part sleeping nude the review. PL and RQ contributed constructive suggestions and extensive language editing.



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