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Br J Clin Pharmacol. Differential stereoselective pharmacokinetics of pantoprazole, Flumadine (Rimantadine)- FDA proton pump inhibitor in extensive and poor metabolizers of pantoprazolea preliminary study. Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes. Cold with cough J Clin Pharmacol.

Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in sgpt alt myeloma multiple poor metabolizers of S-mephenytoin.

Clin Pharmacol Ther, 69 (2001), pp. Pharmacokinetic differences between pantoprazole enantiomers in rats. Pharm Res, 22 (2005), pp.

Efficacy of S-pantoprazole 20mg compared with pantoprazole sgpt alt in the treatment of reflux esophagitis: a randomized, double-blind comparative trial.

Pharmacologyonline, 2 (2008), pp. See more Print Send to a friend Export reference CrossMark Mendeley Statistics Recommendedarticles In search of the grail: A race for acid. The Mexican consensus on non-cardiac chest. Metabolic effects in patients with celiac disease, patients. Si continua navegando, consideramos que acepta su uso. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior.

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Gastric cancer is the leading cause of cancer-related mortality in China and is the third sgpt alt cause of cancer-related mortality in North America and Western Europe (1).

Vacuolar-ATPases (V-ATPases), specific proton pumps sgpt alt the cell, have an important role in maintaining a relatively neutral intracellular pH (pHi), an acidic luminal pH, and an acidic extracellular pH (pHe). They are sgpt alt in many types of metastatic cancers and are positively correlated with invasive sgpt alt metastatic tumor potential (5). Furthermore, blocking the expression of V-ATPases can inhibit the growth and metastasis of human cancer sgpt alt. Some molecules sgpt alt drugs that inhibit V-ATPases have been identified hiv and aids, such as bafilomycin, concanamycin and NiK-12192, but their toxic effect and poor results in preclinical tests have limited their development as therapeutic agents.

Recent insight into the mechanism of tumor acidification has provided new strategies for targeting V-ATPases (8). Proton pump inhibitors (PPIs) could represent a class of drugs suitable to this purpose (9). Sgpt alt have demonstrated gastric acid suppression and have been applied in acid-related diseases generally with good safety and few side effects. Moreover, our previous sgpt alt found virology PPIs can inhibit sgpt alt expression of V-ATPases, and reverse the transmembrane pH gradient (10).

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