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In addition, PAC has the capacity to reduce fever and pain as well as NSAIDs (Messika et al. Although merely anecdotal, there is wide and transnational evidence of patients left at home with mild symptoms for more than a week receiving only PAC until non rem sleep worsening conditions required hospitalization and, not rarely, admission to intensive care units. The routinary use of PAC in at risk categories, along with their intrinsically frail conditions, may have further worsen the scarcity of GSH, especially in western countries where PAC consumption is particularly high.

Such a situation may have rendered this group of population even more susceptible to SARS-CoV2 at the time of its spreading. To this end a merely speculative but intriguing hypothesis is that PAC adoption might have contributed to the high virulence of COVID-19 observed in many EU countries and USA. Notably, in most countries PAC is freely sold as an OTC drug, raising the risk of unintentional abuse and increased adverse effects (Sansgiry et al. These trials, as well as studies aimed at determining the levels of GSH in the plasma of PAC-treated vs -untreated COVID-19 patients should be encouraged.

The preferential use of PAC in COVID-19 as a safer alternative to NSAIDs should be carefully reconsidered and NSAIDs use eventually reappraised. Finally, countries experiencing a new rise of SARS-CoV-2 positive cases such as the four major EU nations and UK, should promote the development of more rational treatment guidelines for COVID-19, taking due account of the above facts and considerations to avoid that the same mistakeif concerns on PAC are ascertainedmay be repeated in the next few months.

Publicly available datasets were analyzed in this study. PS: conceptualization and writing. CF: bibliographic search, revision of the text. Gut-lung axis and non rem sleep in COVID-19. Relationship Between COVID-19 Infection and Liver Injury: A Review of Recent Data. Is glucose-6-phosphate dehydrogenase enzyme deficiency a factor in Coronavirus-19 (COVID-19) infections and deaths.

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Covid-19: ibuprofen should not be used for managing symptoms, say doctors and scientists. Attenuation of influenza-like symptomatology and improvement of cell-mediated prejudices examples with long-term N-acetylcysteine treatment.

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