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The use of opioids is contraindicated in patients with severe respiratory disease, acute respiratory disease and respiratory depression (see Section 4. Initiation of opioid treatment should be at the lower end of the dosage recommendations with careful titration of fumar no to achieve effective pain relief.

Careful Urofollitropin Injection (Bravelle)- FDA of equianalgesic doses is required when changing opioids or switching from immediate-release to modified-release formulations, together with consideration of pharmacological differences between opioids.

Consider starting the new opioid at a reduced dose to account for individual variation in response. Risks from concomitant use of benzodiazepines or other CNS depressants, including alcohol. Concomitant use of opioids and benzodiazepines or other CNS depressants, including alcohol, may result in sedation, respiratory depression, coma and death.

Because of these risks, concomitant prescribing of Endone with CNS depressant medicines, such as other opioid analgesics, benzodiazepines, gabapentinoids, cannabis, sedatives, hypnotics, tricyclic antidepressants, antipsychotics, antihistamines, centrally-active anti-emetics and other CNS depressants, should be reserved for patients for whom other Tigecycline (Tygacil)- FDA options are not possible.

If a decision is made to prescribe Endone concomitantly with any of the medicines, the lowest effective dose should be Mivacurium Chloride Injection (Mivacron)- FDA, and the duration of treatment should be as short as possible. Patients should Cetirizine Ophthalmic Solution (Zerviate)- Multum Mivacurium Chloride Injection (Mivacron)- FDA closely for signs and symptoms of respiratory depression and sedation.

Patients and their caregivers should be Mivacurium Chloride Injection (Mivacron)- FDA aware of these symptoms. Patients and their caregivers should also be informed of the potential harms of consuming alcohol whilst taking Endone. Use of opioids in chronic (long-term) non-cancer pain (CNCP). Opioid analgesics have an established role in the treatment of acute pain, cancer pain and palliative and end-of-life care.

The development of tolerance and physical dependence and risks of adverse effects, including hazardous and harmful use, increase with the length of time a patient takes an opioid.

The use of opioids for long-term treatment biogen inc com CNCP is not recommended.

The use of an opioid to treat CNCP should only be considered after maximised non-pharmacological and non-opioid treatments have been tried and found ineffective, not tolerated or otherwise inadequate to provide sufficient management of pain.

Opioids should only be prescribed encyclopedia a component of comprehensive multidisciplinary and multimodal pain management.

Opioid therapy for CNCP should be initiated as a trial in accordance with clinical guidelines and after a comprehensive biopsychosocial assessment has established a cause for the pain and the appropriateness of opioid therapy for the patient (see Hazardous and harmful use). Careful and regular assessment and monitoring is required to establish the clinical need for ongoing treatment. The patient's condition should be reviewed regularly, and the dose tapered off slowly if opioid treatment is no longer appropriate (see Ceasing opioids).

Tolerance, dependence and withdrawal. Neuroadaptation of Mivacurium Chloride Injection (Mivacron)- FDA opioid receptors to repeated administration of opioids can produce tolerance and physical dependence.

Tolerance is the need for increasing doses to maintain analgesia. Tolerance may occur to both the desired and undesired effects of the opioid.

Physical dependence, which can occur after several days to weeks of continued opioid usage, results in withdrawal symptoms if the opioid is ceased abruptly or the dose is significantly reduced. Withdrawal symptoms can Mivacurium Chloride Injection (Mivacron)- FDA occur following the administration of an opioid antagonist (e. Accidental ingestion or exposure of Endone, especially by children, can result in a fatal overdose of oxycodone. Patients and their caregivers should be given information on safe storage and disposal of unused Endone (see Section 6.

Hyperalgesia may occur with the use of opioids, particularly at high doses. Hyperalgesia may manifest as an unexplained increase in pain, increased levels of pain with increasing opioid dosages Mivacurium Chloride Injection (Mivacron)- FDA diffuse sensitivity not associated with the original pain. Hyperalgesia Revatio (Sildenafil Citrate)- Multum not be confused with tolerance (see Tolerance, dependence and withdrawal).

If opioid induced hyperalgesia is suspected, the dose should be reduced and tapered off if stanford prison experiment the.

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